The airline is to operate a twice-weekly service to Katowice in Poland from June 26 on Mondays and Fridays.
The route will be served with a 180-seat Airbus A320 with fares starting at £25.99 one way.
Bristol airport aviaition director Shaun Browne said: “We are delighted to welcome Wizz Air to the southwest of the UK.
“The Katowice service will be a popular addition to the route network available from Bristol Airport, further strengthening links with Poland.”
A Wizz Air spokesman said: “With six UK airports, the Wizz low-cost offer is a great opportunity for UK consumers explore central and eastern Europe and we look forward to carrying many passengers on our new Bristol-Katowice service.”
Sourced from Travel Weekly